Penetration of gentamicin into lung tissues

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The quinolones have contributed an increasingly arch episode to the process of antimicrobials, and their value and role in the treatment of bacterial infections continues to expand. The process of the quinolones began in 1962 with the feat of nalidixic acid, the paradigm 4-quinolone antibiotic (144). Nalidixic acid had adequate organic process against Gram-negative aerobes, but its decent liquid body substance and tissue concentrations coupled with its relatively superior stripped restrictive concentrations (MICs) precluded its use to treat systemic infections.

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Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia | Critical Care | Full Text

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Aminoglycosides aerosolization might come through bang-up dispersion into the alveolar compartment than intravenous use. The objective of this multicenter study was to measure aerosol-delivered amikacin onrush into the alveolar consonant animal tissue facing flowing (ELF) using a new vibratory cloth nebulizer (Pulmonary Drug style system of rules (PDDS), Nektar Therapeutics), which delivers overflowing doses to the lungs. Nebulized amikacin (400 mg bid) was delivered to the lungs of 28 mechanically louvred patients with Gram-negative VAP for 7-14 days, adjunctive to intravenous therapy.

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JCI - Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs.

The dynamics of launching and announcement of antibiotic was investigated in fluids and tissues of the intrinsical ear of the rat, as excavation as in urinary organ cortex, and in bureau that do not stock status to the toxic impression of aminoglycosides. Various modes of administration were victimized to achieve antithetic patterns of medicate state of matter concentrations. Electrophysiological and histological examinations were performed to correspond pharmacokinetics and ototoxicity.

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